Multiple Myeloma Research Foundation (MMRF) CoMMpass Study

The Multiple Myeloma Research Foundation’s CoMMpass Study is a multicenter, multinational, large-scale, longitudinal study in newly-diagnosed multiple myeloma (MM) with more than 1,000 patients enrolled.

VAI’s Pathology and Biorepository Core serves as the biorepository for this study, and provides support through biospecimen collection kit production, distribution and tracking, biospecimen receipt, handling and storage, processing blood and bone marrow to analytes (such as DNA and RNA), and the distribution of analytes for genomic characterization. Data from the CoMMpass Study is made available to researchers via the MMRF’s Researcher Gateway, an online, open-access portal designed to make key genomic and clinical data available for additional study.

Project-associated publications

Manojlovic Z, Christofferson A, Liang WS, Aldrich J, Washington M, Wong S, Rohrer DJewell S, Kittles RA, Derome M, Auclair D, Craig DW, Keats J, Carpten JD. 2017. Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent casesPLoS Genet 13(11):e1007087.

Keats J, Speyer G, Christofferson A, Stephenson K, Kurdoglu A, Russell M, Aldrich J, Legendre C, Cuyugan L, Adkins J, McDonald J, Helland A, Blanksi AHodges MRohrer D, Jagannath S, Siegel D, Vij R, Orloff G, Zimmerman T, Niesvizky R, Liles D, Fay J, Wolf J, Rifin R, Derome M, Auclair D, Liang W, Kim S, Guiterrez N, Kidd P, Jewell S, Craig D, Carpten J, Lonial S. 2015. Interim analysis of the MMRF CoMMpass Study: Comprehensive characterization of multiple myeloma patients at diagnosis reveals distinct molecular subtypes and clinicial outcomesClin Lymphoma Myeloma Leuk 15:e44–e45.