VARI’s Pathology and Biorepository Core integrates anatomic pathology expertise with biorepository and biospecimen science for investigator- and project-driven research. The Core builds upon strengths in standard histology, microscopy and biobanking, along with novel technologies to test and apply best practices in biospecimen science. The Core’s focus on pathology and molecular quality metrics provide complementary emphasis on high-quality biospecimens and interpretable results with which to validate experimental models and extend them to clinical samples, thereby advancing the Institute’s mission to improve the health and enhance the lives of current and future generations.
The Pathology and Biorepository Core is led by Dr. Scott Jewell, who has extensive expertise in experimental pathology, immunology and biobanking, and Associate Director of Pathology Dr. Galen Hostetter, a board-certified pathologist with NIH fellowship training in medical genetics. They have ongoing studies on the effects of pre-analytical variables in tissue collection and transport that affect the integrity of downstream analytes. The assessment of oncogenes and immunomodulators in tumor tissues and the application of genomic and epigenomic assays for biospecimens also are among the Core’s services.
VARI’s Biorepository is nationally and internationally recognized, once serving as the NCI Comprehensive Biospecimen Resource for the Cancer Human Biobank (caHUB), the Biospecimen Pre-analytical Variables Program and the Genomic Tissue Expression (GTEx)
project, and presently as the Biospecimen Core Resource for the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC). It also provides biorepository services for the Multiple Myeloma Research Foundation and the Tuberous Sclerosis Alliance.
VARI’s Biorepository has been accredited by the College of American Pathologists (CAP) since 2012. Its accreditation number is 8017856.
Authors who publish articles containing work performed by VARI’s Core Technologies and Services are asked to follow these guidelines in their acknowledgements: