Pathology and Biorepository Core


Mathieson W, Mommaerts K, Trouet JM, Mathay C, Guan P, Carithers LJ, Rohrer D, Valley DR, Blanski A, Jewell S, Moore HM, Betsou F. 2018. Cold ischemia score: An mRNA assay for the detection of extended cold ischemia in formalin-fixed, paraffin-embedded tissue. J Histochem Cytochem 18:22155418819967.

Manojlovic Z, Christofferson A, Liang WS, Aldrich J, Washington M, Wong S, Rohrer D, Jewell S, Kittles RA, Derome M, Auclair D, Craig DW, Keats J, Carpten JD. 2017. Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases. PLoS Genet 13(11):e1007087.

GTEx Consortium. 2015. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humansScience. 348(6235):648–660.
*Core contributions: Dana Valley, Dan Rohrer and Scott Jewell

Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA, Compton CC, DeLuca DS, Peter-Demchok J, Gelfand ET, Guan P, Korzeniewski GE, Lockhart NC, Rabiner CA, Rao AK, Robinson KL, Roche NV, Sawyer SJ, Segré A, Shive CE, Smith AM, Sobin LH, Undale AH, Valentino KM, Vaught J, Young TR, Moore HM, on behalf of the GTEx Consortium. 2015. A novel approach to high-quality post-mortem tissue procurement: The GTEx ProgramBiopreserv Biobank 13(5):311–319. 
*Core contributions: Dana Valley, Dan Rohrer and Scott Jewell

Keats J, Speyer G, Christofferson A, Stephenson K, Kurdoglu A, Russell M, Aldrich J, Legendre C, Cuyugan L, Adkins J, McDonald J, Helland A, Blanksi AHodges MRohrer D, Jagannath S, Siegel D, Vij R, Orloff G, Zimmerman T, Niesvizky R, Liles D, Fay J, Wolf J, Rifin R, Derome M, Auclair D, Liang W, Kim S, Guiterrez N, Kidd P, Jewell S, Craig D, Carpten J, Lonial S. 2015. Interim analysis of the MMRF CoMMpass Study: Comprehensive characterization of multiple myeloma patients at diagnosis reveals distinct molecular subtypes and clinical outcomesClin Lymphoma Myeloma Leuk 15:e44–e45.

Robb JA, Gulley ML, Fitzgibbons PL, Kennedy MF, Cosentino LM, Washington K, Dash RC, Branton PA, Jewell SD, Lapham RL. 2014. A call to standardize preanalytic data elements for biospecimens. Arch Pathol Lab Med 138:526–537. 

Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, (including Jewell, SD) et al. 2013. The Genotype-Tissue Expression (GTEx) project. Nature Genetics 45(6): 580–585. 

Jewell SD, Cordial CR. 2013. Silver staining of nucleolar organizer regions. J Histotech 19:241–256. 

Resau, JH, Ho NT, Dykema K, Faber MS, Busik JV, Nickolov RZ, Furge KA, Paneth N, Jewell S, Khoo SK.  2012. Evaluation of sex-specific gene expression in archived dried blood spots (DBS). Int J Mol Sci 13(8):9599-9608.

Edelman MJ, Hodgson L, Wang X, Christenson R, Jewell SD, Vokes E, Kratzke R. 2011. Serum vascular endothelial growth factor and COS-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304. J Thorac Oncol 6(11):1902–1906. 

Moore HM, Kelly AB, Jewell SD, McShane LM, Clark DP, Greenspan R, Hayes DF, Hainaut P, Kim P, Mansfield E, Potapova O, Riegman P, Rubinstein Y, Seijo E, Somiari S, Watson P, Weier HU, Zhu C, Vaught J. 2011. Biospecimen reporting for improved study quality (BRISQ). J Proteome Res. 10(8):3429–3438.

Moore HM, Kelly A, Jewell SD, McShane LM, Clark DP, Greenspan R, Hainaut P, Hayes DF, Kim P, Mansfield E, Potapova O, Riegman P, Rubinstein Y, Seijo E, Somiari S, Watson P, Weier HU, Zhu C, Vaught J. 2011. Biospecimen reporting for improved study quality. Biopreserv Biobank 9(1):57–70. 

Moore HM, Kelly AB, Jewell SD McShane LM, Clark DP, Greenspan R, Hayes DF, Hainaut P, Kim P, Mansfield EA, Potapova O, Riegman P, Rubinstein Y, Seijo E, Somiari S, Watson P, Weier HU, Zhu C, Vaught J. 2011. Biospecimen reporting for improved study quality (BRISQ). Cancer Cytopathol 119(2):92-101. 

Rimm DL, Nielsen TO, Jewell SD, Rohrer D, Broadwater G, Waldman F, Mitchell KA, Singh B,  Tsongalis GJ, Frankel WL, Magliocco A, Lara JF, Hsi ED, Bleiweiss I, Badve SS, Chen B, Ravdin P, Schilsky R,  Thor A, Berry DA. 2011. CALGB Pathology Committee guidelines for tissue microarray construction representing multi-center prospective clinical trial tissues for cancer and leukemia group B, Eastern Oncology Group, Southwest Oncology Group, and North Central Cancer Treatment Group. J Clin Oncol 29(16):2282–2290. 

Khleif SN, Doroshow JH, Hait WN, AACR-FDA-NCI Cancer Biomarkers Collaborative*. 2010. AACR-FDA-NCI Cancer Biomarkers Collaborative consensus report: advancing the use of biomarkers in cancer drug development. Clin Cancer Res. 16(13):3299–3318.
*122 co-investigators. Jewell SD served as co-chair of Biospecimen Subcommittee

Leyland-Jones BR, Ambrosone CB, Bartlett J, Matthew JC, Ellis R, Enos RA, Raji A, Pins MR, Zujewski JA, Hewitt SM, Forbes JF, Abramovitz M, Braga S, Cardoso F, Harbeck N, Denkert C, Jewell SD. 2008. Recommendations for collection and handling of specimens from group breast cancer clinical trials.  J Clinl Oncol 26(10):1–7.

Szafranska AE, Davison TS, Shingara J, Doleshal M, Riggenbach JA, Morrison CD, Jewell SD, Labourier E. 2008. Accurate molecular characterization of formalin-fixed, paraffin-embedded tissues by microRNA expression profiling.  J Mol Diag10(5): 415–423. 

Jewell SD, Monovich LC, Edgerton MA, Schilsky RL, Dressler LG. 2005. Biospecimen banking, standardization, and lessons learned from the Cancer and Leukemia Group B Pathology Coordinating Office. Sem Breast Dis. 8(2):93–99.

Srinivasan M, Sedmak DD, Jewell SD. 2002. Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Amer J Pathol 161(6):1961–1971. 

Jewell SD, Srinivasan, M, McCart LM, Williams N, Grizzle WH, LiVolsi V, McClennan G and Sedmak DD. 2002. Analysis of the molecular quality of human tissues: An experience from the Cooperative Human Tissue Network. Am J Clin Pathol 118(5):733–741. 

Schilsky R, Dressler LM, Bucci D, Monovich L, Jewell S, Suster S, Caligiuri MA, Kantoff P, Compton C. 2002. Cooperative group tissue banks as research resources: The Cancer and Leukemia Group B Tissue Repositories. Clin Cancer Res 8(5):943–948.

Jewell SD, Gienapp IE, Cox KL, Whitacre CC. 1998. Oral tolerance as therapy for experimental autoimmune encephalomyelitis and multiple sclerosis: demonstration of T cell anergy. Immunolm Cell Biol 76:74–82.

PATHOLOGY (selected publications)

Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ. 2018. KRAS suppression-induced degradation of MYC is antagonized by a MEK5-ERK5 compensatory mechanism. Can Cell 34(5):807-822.

Mukherjee A, Patterson AL, George JW, Carpenter TJ, Madaj ZB, Hostetter G, Risinger JI, Teixeira JM. 2018. Nuclear PTEN localization contributes to DNA damage response in endometrial adenocarcinoma and could have a diagnostic benefit for therapeutic management of the disease. Mol Cancer Ther 17(9):1995–2003.

Harlow ML, Maloney N, Roland J, Guillen Navarro MJ, Easton MK, Kitchen-Goosen SM, Boguslawski EA, Madaj ZB, Johnson BK, Bowman MJ, D’Incalci M, Winn ME, Turner L, Hostetter G, Galmarini CM, Aviles PM, Grohar PJ. 2016. Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus. Cancer Res 76(22):6657–6668. 

Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X. 2016. Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasisOncogene 35(18):2370-2377. 

Ensink E, Sinha J, Sinha A, Tang H, Calderone HM, Hostetter G, Winter J, Cherba D, Brand RE, Allen PJ, Sempere LF, Haab BB. 2015. Segment and fit thresholding: a new method for image analysis applied to microarray and immunofluorescence dataAnal Chem 87(19):9715-9721.

Valkenburg KC, Hostetter G, Williams BO. 2015. Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice. Prostate75)14):1579–1580. 

Hostetter G, Collins E, Varlan P, Edewaard E, Harbach PR, Hudson EA, Feenstra KJ, Turner LM, Berghuis BD, Resau JH, Jewell SD. 2014. Veterinary and human biobanking practices: enhancing molecular sample integrity. Vet Pathol 51(1): 270–280. 

MacKenzie TA, Schwartz GN, Calderone HM, Graveel CR, Winn ME, Hostetter G, Wells WA, Sempere LF. 2014. Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer. Am J Path 184(12):3217–3225. 

Berger PL, Frank SB, Schulz VV, Nollet EA, Edick MJ, Holly B, Chang TA, Hostetter G, Kim S, Miranti CK.  2014. Transient induction of ING4 by MYC drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesisCancer Res 74(12): 3357–3368. 

Spivak-Kroizman TR, Hostetter G, Posner R, Aziz M, Hu C, Demeure MJ, Von Hoff D, Hingorani SR, Palculict TB, Izzo J, Kiriakova GM, Abdelmelek M, Bartholomeusz G, James BP, Powis G. 2013. Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancerCancer Res 73(11):3235-47. 

Weiss GJ, Liang WS, Demeure MJ, Kiefer JA, Hostetter G, Izatt T, Sinari S, Christoforides A, Aldrich J, Kurdoglu A, Phillips L, Benson H, Reiman R, Baker A, Marsh V, Von Hoff DD, Carpten JD, Craig DW.  2013. A pilot study using next-generation sequencing in advanced cancers: feasibility and challenges.  PLoS One 8(10):e76438. 

Cao Y, Zhang ZL, Zhou M, Elson P, Rini B, Aydin H, Feenstra K, Tan MH, Berghuis B, Tabbey R, Resau JH, Zhou FJ, Teh BT, Qian CN. 2013. Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinomaCancer 119(2):313-324. 

Raz G, Allen KE, Kingsley C, Cherni I, Arora S, Watanabe A, Lorenzo CD, Edwards V DK, Sridhar S, Hostetter G, Weiss GJ. 2012. Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancerLung Cancer 76(2):191-196. 

Byron SA, Min E, Thal TS, Hostetter G, Watanabe AT, Azorsa DO, Little TH, Tapia C, Kim S. 2012. Negative regulation of NF-κB by the ING4 tumor suppressor in breast cancerPLoS One. 7(10):e46823.

Weiss GJ, Liang WS, Izatt T, Arora S, Cherni I, Raju RN, Hostetter G, Kurdoglu A, Christoforides A, Sinari S, Baker AS, Metpally R, Tembe WD, Phillips L, Von Hoff DD, Craig DW, Carpten JD. 2012. Paired tumor and normal whole genome sequencing of metastatic olfactory neuroblastoma. PLoS One 7(5):e37029. 

Asmann YW, Necela BM, Kalari KR, Hossain A, Baker TR, Carr JM, Davis C, Getz JE, Hostetter G, Li X, McLaughlin SA, Radisky DC, Schroth GP, Cunliffe HE, Perez EA, Thompson EA. 2012. Detection of redundant fusion transcripts as biomarkers or disease-specific therapeutic targets in breast cancerCancer Res 72(8):1921-1928. 

Stephens B, Anthony SP, Han H, Kiefer J, Hostetter G, Barrett M, Von Hoff DD. 2012. Molecular characterization of a patient’s small cell carcinoma of the ovary of the hypercalcemic type. J Cancer. 3:58-66. 

Diep CH, Zucker KM, Hostetter G, Watanabe A, Hu C, Munoz RM, Von Hoff DD, Han H. 2012. Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. PLoS One 7(3):e32783. 

Savage SJ, Hostetter G. 2011. Genomic analysis by oligonucleotide array Comparative Genomic Hybridization utilizing formalin-fixed, paraffin-embedded tissuesMethods Mol Biol 700:185-98. 

Bapat AA, Hostetter G, Von Hoff D, Han H. 2011. Perineural invasion and associated pain in pancreatic cancerNat Rev Cancer 11(10):695-707. 

Whatcott CJ, Han H, Posner RG, Hostetter G, Von Hoff D. 2011. Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second lookCancer Discov 1(4):291-296. 

Savage SJ, Hostetter G.  2011. Genomic analysis by oligonucleotide array Comparative Genomic Hybridization utilizing formalin-fixed, paraffin-embedded tissues. Methods Mol Biol 700:185-198. 

Harris CA, Resau JH, Hudson EA, West RA, Moon C, Black AD, McAllister JP. 2011. Effects of surface wettability, flow, and protein concentration on macrophage and astrocyte adhesion in an in vitro model of central nervous system catheter obstruction. J Biomed Mater Res 97A: 433-440. 

Harris CA, Resau JH, Hudson EA, West RA, Moon C, Black AD, McAllister JP. 2011. Reduction of protein adsorption and macrophage and astrocyte adhesion on ventricular catheters by polyethylene glycol and N-aceytl-L-cysteine. J Biomed Mater Res 98A(4):425-433. 

He Y, Xu Y, Zhang C, Gao X, Dykema KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, Xu HE. 2011. Identification of a lysosomal pathway that modulates glucocorticoid signaling and inflammation responseSci Signal 4(180):ra44. 

Hostetter G, Kim S, Savage S, Gooden G, Alla L, Barrett M, Zhang J, Watanabe A, Einspahr J, Alberts D, Prasad A, Nickoloff B, Carpten J, Trent J, Bittner M. 2010. Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samplesNucleic Acids Res 38(2):e9. 

Demeure MJ, Sielaff T, Koep L, Prinz R, Moser AJ, Zeh H, Hostetter G, Black J, Decker A, Rosewell R, Bussey K, Von Hoff, DD. 2010. Multi-institutional tumor banking: lessons learned from a pancreatic cancer biospecimens repository. Pancreas 39(7): 949-954. 

Wen F, Shen A, Shanas R, Bhattacharyya A, Lian F, Hostetter G, Shi J.  2010. Higher expression of the heterogeneous nuclear ribonucleoprotein K in melanoma. Ann Surg Oncol 17(10):2619- 27. 

Hostetter G, Kim S, Savage S, Gooden G, Alla L, Barrett M, Zhang J, Watanabe A, Einspahr J, Alberts D, Prasad A, Nickoloff B, Carpten J, Trent J, Bittner M. 2010. Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples. Nucleic Acids Res 38(2):e9. 

Harris CA, Resau JH, Hudson EA, West RA, Moon C, McAllister JP. 2010. Mechanical contributions to astrocyte adhesion using a novel in vitro model of catheter obstruction. Exp Neurol 222(2): 204-210. 

Wang X, Wang S, Tang X, Zhang A, Grabinski T, Guo Z, Hudson EA, Berghuis B, Webb CP, Zhao P, Cao B. 2010. Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients. J Immunol Methods 362(1-2):151-160. 

Knudsen BS, Zhao P, Resau J, Cottingham S, Gherardi E, Xu E, Berguis B, Daugherty J, Grabinski T, Toro J, Giambernardi T, Skinner RS, Gross M, Hudson EA, Kort E, Lengyel E, Ventura A, West RA, Xie Q, Hay R, Vande Woude GF, Cao B. 2009. A novel multipurpose monoclonal antibody for evaluating human c-MET expression in preclinical and clinical settings. Appl Immunohistochem Mol Morph 17(1): 57-67.

Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE. 2007. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448(7152):439-444.

Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, Hostetter G, Harvey J, Taubman MB. 2007. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res 13(10):2870-2875. 

Tran NL, McDonough WS, Savitch BA, Fortin SP, Winkles JA, Symons M, Nakada M, Cunliffe HE, Hostetter G, Hoelzinger DB, Rennert JL, Michaelson JS, Burkly LC, Lipinski CA, Loftus JC, Mariani L, Berens ME. 2006. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and Nuclear Factor-{kappa}B and correlate with poor patient outcome. Cancer Res 66(19):9535-9542.

Watanabe A, Cornelison R, Hostetter G. 2005. Tissue microarrays: applications in genomic research. Expert Rev Mol Diagn 5(2):171-81.

Hu YC, Komorowski RA, Graewin S, Hostetter G, Kallioniemi OP, Pitt HA, Ahrendt SA. 2003. Thymidylatesynthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancerClin Cancer Res 9(11):4165-4171. 

Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, Moses TY, Hostetter G, Wagner U, Kakareka J, Salem G, Pohida T, Heenan P, Duray P, Kallioniemi O-P, Hayward NK, Trent JM, Meltzer PS. 2003. High frequency of BRAF mutations in neviNat Genet 33:19-3320.

Weeraratna A, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM. 2002. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Can Cell 1(3):279-288.

Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephen D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, DeMarzo A, Papadopoulous N, Kallioniemi O-P, Burk R, Meyers D, Gronberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J. 2002. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet 30:181-184. 

Andersen CL, Hostetter G, Grigoryan A, Sauter G, Kallioniemi A. 2001. Improved protocol for fluorescence in situ hybridization on tissue microarrays. Cytometry 45:83-86.