616.234.5000

Publications

Pathology and Biorepository Core

BIOREPOSITORY AND BIOSPECIMEN SCIENCE (selected publications)

GTEx Consortium. 2015. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 348(6235):648–660. PubMed
*Core contributions: Dana Valley, Dan Rohrer and Scott Jewell

Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA, Compton CC, DeLuca DS, Peter-Demchok J, Gelfand ET, Guan P, Korzeniewski GE, Lockhart NC, Rabiner CA, Rao AK, Robinson KL, Roche NV, Sawyer SJ, Segré A, Shive CE, Smith AM, Sobin LH, Undale AH, Valentino KM, Vaught J, Young TR, Moore HM, on behalf of the GTEx Consortium. 2015. A novel approach to high-quality post-mortem tissue procurement: The GTEx Program. Biopreserv Biobank 13(5):311–319. PubMed
*Core contributions: Dana Valley, Dan Rohrer and Scott Jewell

Keats J, Speyer G, Christofferson A, Stephenson K, Kurdoglu A, Russell M, Aldrich J, Legendre C, Cuyugan L, Adkins J, McDonald J, Helland A, Blanksi AHodges MRohrer D, Jagannath S, Siegel D, Vij R, Orloff G, Zimmerman T, Niesvizky R, Liles D, Fay J, Wolf J, Rifin R, Derome M, Auclair D, Liang W, Kim S, Guiterrez N, Kidd P, Jewell S, Craig D, Carpten J, Lonial S. 2015. Interim analysis of the MMRF CoMMpass Study: Comprehensive characterization of multiple myeloma patients at diagnosis reveals distinct molecular subtypes and clinical outcomes. Clin Lymphoma Myeloma Leuk 15:e44–e45. Article

Robb JA, Gulley ML, Fitzgibbons PL, Kennedy MF, Cosentino LM, Washington K, Dash RC, Branton PA, Jewell SD, Lapham RL. 2014. A call to standardize preanalytic data elements for biospecimens. Arch Pathol Lab Med 138:526–537. PubMed

Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, (including Jewell, SD) et al. 2013. The Genotype-Tissue Expression (GTEx) project. Nature Genetics 45(6): 580–585. PubMed

Jewell SD, Cordial CR. 2013. Silver staining of nucleolar organizer regions. J Histotech 19:241–256. PubMed

Resau, JH, Ho NT, Dykema K, Faber MS, Busik JV, Nickolov RZ, Furge KA, Paneth N, Jewell S, Khoo SK.  2012. Evaluation of sex-specific gene expression in archived dried blood spots (DBS). Int J Mol Sci 13(8):9599-9608. PubMed

Edelman MJ, Hodgson L, Wang X, Christenson R, Jewell SD, Vokes E, Kratzke R. 2011. Serum vascular endothelial growth factor and COS-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304. J Thorac Oncol 6(11):1902–1906. PubMed

Moore HM, Kelly AB, Jewell SD, McShane LM, Clark DP, Greenspan R, Hayes DF, Hainaut P, Kim P, Mansfield E, Potapova O, Riegman P, Rubinstein Y, Seijo E, Somiari S, Watson P, Weier HU, Zhu C, Vaught J. 2011. Biospecimen reporting for improved study quality (BRISQ). J Proteome Res. 10(8):3429–3438. PubMed

Moore HM, Kelly A, Jewell SD, McShane LM, Clark DP, Greenspan R, Hainaut P, Hayes DF, Kim P, Mansfield E, Potapova O, Riegman P, Rubinstein Y, Seijo E, Somiari S, Watson P, Weier HU, Zhu C, Vaught J. 2011. Biospecimen reporting for improved study quality. Biopreserv Biobank 9(1):57–70. PubMed

Moore HM, Kelly AB, Jewell SD McShane LM, Clark DP, Greenspan R, Hayes DF, Hainaut P, Kim P, Mansfield EA, Potapova O, Riegman P, Rubinstein Y, Seijo E, Somiari S, Watson P, Weier HU, Zhu C, Vaught J. 2011. Biospecimen reporting for improved study quality (BRISQ). Cancer Cytopathol 119(2):92-101. PubMed

Rimm DL, Nielsen TO, Jewell SD, Rohrer D, Broadwater G, Waldman F, Mitchell KA, Singh B,  Tsongalis GJ, Frankel WL, Magliocco A, Lara JF, Hsi ED, Bleiweiss I, Badve SS, Chen B, Ravdin P, Schilsky R,  Thor A, Berry DA. 2011. CALGB Pathology Committee guidelines for tissue microarray construction representing multi-center prospective clinical trial tissues for cancer and leukemia group B, Eastern Oncology Group, Southwest Oncology Group, and North Central Cancer Treatment Group. J Clin Oncol 29(16):2282–2290.  PubMed

Khleif SN, Doroshow JH, Hait WN, AACR-FDA-NCI Cancer Biomarkers Collaborative*. 2010. AACR-FDA-NCI Cancer Biomarkers Collaborative consensus report: advancing the use of biomarkers in cancer drug development. Clin Cancer Res. 16(13):3299–3318. PubMed
*122 co-investigators. Jewell SD served as co-chair of Biospecimen Subcommittee

Leyland-Jones BR, Ambrosone CB, Bartlett J, Matthew JC, Ellis R, Enos RA, Raji A, Pins MR, Zujewski JA, Hewitt SM, Forbes JF, Abramovitz M, Braga S, Cardoso F, Harbeck N, Denkert C, Jewell SD. 2008. Recommendations for collection and handling of specimens from group breast cancer clinical trials.  J Clinl Oncol 26(10):1–7. PubMed

Szafranska AE, Davison TS, Shingara J, Doleshal M, Riggenbach JA, Morrison CD, Jewell SD, Labourier E. 2008. Accurate molecular characterization of formalin-fixed, paraffin-embedded tissues by microRNA expression profiling.  J Mol Diag10(5): 415–423. PubMed

Jewell SD, Monovich LC, Edgerton MA, Schilsky RL, Dressler LG. 2005. Biospecimen banking, standardization, and lessons learned from the Cancer and Leukemia Group B Pathology Coordinating Office. Sem Breast Dis. 8(2):93–99. Article

Srinivasan M, Sedmak DD, Jewell SD. 2002. Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Amer J Pathol 161(6):1961–1971. PubMed

Jewell SD, Srinivasan, M, McCart LM, Williams N, Grizzle WH, LiVolsi V, McClennan G and Sedmak DD.   2002. Analysis of the molecular quality of human tissues: An experience from the Cooperative Human Tissue Network. Am J Clin Pathol 118(5):733–741. PubMed

Schilsky R, Dressler LM, Bucci D, Monovich L, Jewell S, Suster S, Caligiuri MA, Kantoff P, Compton C. 2002. Cooperative group tissue banks as research resources: The Cancer and Leukemia Group B Tissue Repositories. Clin Cancer Res 8(5):943–948. PubMed

Jewell SD, Gienapp IE, Cox KL, Whitacre CC. 1998. Oral tolerance as therapy for experimental autoimmune encephalomyelitis and multiple sclerosis: demonstration of T cell anergy. Immunolm Cell Biol 76:74–82. PubMed

PATHOLOGY (selected publications)

Harlow ML, Maloney N, Roland J, Guillen Navarro MJ, Easton MK, Kitchen-Goosen SM, Boguslawski EA, Madaj ZB, Johnson BK, Bowman MJ, D’Incalci M, Winn ME, Turner L, Hostetter G, Galmarini CM, Aviles PM, Grohar PJ. 2016. Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus. Cancer Res 76(22):6657–6668. PubMed

Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X. 2016. Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis.  Oncogene 35(18):2370-2377.  PubMed

Ensink E, Sinha J, Sinha A, Tang H, Calderone HM, Hostetter G, Winter J, Cherba D, Brand RE, Allen PJ, Sempere LF, Haab BB. 2015. Segment and fit thresholding: a new method for image analysis applied to microarray and immunofluorescence data.  Anal Chem 87(19):9715-9721. PubMed

Valkenburg KC, Hostetter G, Williams BO. 2015. Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice. Prostate75)14):1579–1580. PubMed

Hostetter G, Collins E, Varlan P, Edewaard E, Harbach PR, Hudson EA, Feenstra KJ, Turner LM, Berghuis BD, Resau JH, Jewell SD.  2014. Veterinary and human biobanking practices: enhancing molecular sample integrity. Vet Pathol 51(1): 270–280. PubMed

MacKenzie TA, Schwartz GN, Calderone HM, Graveel CR, Winn ME, Hostetter G, Wells WA, Sempere LF. 2014. Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer. Am J Path 184(12):3217–3225. PubMed

Berger PL, Frank SB, Schulz VV, Nollet EA, Edick MJ, Holly B, Chang TA, Hostetter G, Kim S, Miranti CK.  2014. Transient induction of ING4 by MYC drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.  Cancer Res 74(12): 3357–3368. PubMed

Spivak-Kroizman TR, Hostetter G, Posner R, Aziz M, Hu C, Demeure MJ, Von Hoff D, Hingorani SR, Palculict TB, Izzo J, Kiriakova GM, Abdelmelek M, Bartholomeusz G, James BP, Powis G.  2013. Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res 73(11):3235-47. PubMed

Weiss GJ, Liang WS, Demeure MJ, Kiefer JA, Hostetter G, Izatt T, Sinari S, Christoforides A, Aldrich J, Kurdoglu A, Phillips L, Benson H, Reiman R, Baker A, Marsh V, Von Hoff DD, Carpten JD, Craig DW.  2013. A pilot study using next-generation sequencing in advanced cancers: feasibility and challenges.  PLoS One 8(10):e76438. PubMed

Cao Y, Zhang ZL, Zhou M, Elson P, Rini B, Aydin H, Feenstra K, Tan MH, Berghuis B, Tabbey R, Resau JH, Zhou FJ, Teh BT, Qian CN. 2013. Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma. Cancer 119(2):313-324. PubMed

Raz G, Allen KE, Kingsley C, Cherni I, Arora S, Watanabe A, Lorenzo CD, Edwards V DK, Sridhar S, Hostetter G, Weiss GJ. 2012. Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer. Lung Cancer 76(2):191-196. PubMed

Byron SA, Min E, Thal TS, Hostetter G, Watanabe AT, Azorsa DO, Little TH, Tapia C, Kim S. 2012. Negative regulation of NF-κB by the ING4 tumor suppressor in breast cancer.  PLoS One. 7(10):e46823. PubMed

Weiss GJ, Liang WS, Izatt T, Arora S, Cherni I, Raju RN, Hostetter G, Kurdoglu A, Christoforides A, Sinari S, Baker AS, Metpally R, Tembe WD, Phillips L, Von Hoff DD, Craig DW, Carpten JD. 2012. Paired tumor and normal whole genome sequencing of metastatic olfactory neuroblastoma. PLoS One 7(5):e37029. PubMed

Asmann YW, Necela BM, Kalari KR, Hossain A, Baker TR, Carr JM, Davis C, Getz JE, Hostetter G, Li X, McLaughlin SA, Radisky DC, Schroth GP, Cunliffe HE, Perez EA, Thompson EA. 2012. Detection of redundant fusion transcripts as biomarkers or disease-specific therapeutic targets in breast cancer.  Cancer Res 72(8):1921-1928. PubMed

Stephens B, Anthony SP, Han H, Kiefer J, Hostetter G, Barrett M, Von Hoff DD. 2012. Molecular characterization of a patient’s small cell carcinoma of the ovary of the hypercalcemic type. J Cancer. 3:58-66. PubMed

Diep CH, Zucker KM, Hostetter G, Watanabe A, Hu C, Munoz RM, Von Hoff DD, Han H. 2012. Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. PLoS One 7(3):e32783. PubMed

Savage SJ, Hostetter G. 2011. Genomic analysis by oligonucleotide array Comparative Genomic Hybridization utilizing formalin-fixed, paraffin-embedded tissues. Methods Mol Biol 700:185-98. PubMed

Bapat AA, Hostetter G, Von Hoff D, Han H. 2011. Perineural invasion and associated pain in pancreatic cancer. Nat Rev Cancer 11(10):695-707. PubMed

Whatcott CJ, Han H, Posner RG, Hostetter G, Von Hoff D. 2011. Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look.  Cancer Discov 1(4):291-296. PubMed

Savage SJ, Hostetter G.  2011. Genomic analysis by oligonucleotide array Comparative Genomic Hybridization utilizing formalin-fixed, paraffin-embedded tissues. Methods Mol Biol 700:185-198. PubMed

Harris CA, Resau JH, Hudson EA, West RA, Moon C, Black AD, McAllister JP. 2011. Effects of surface wettability, flow, and protein concentration on macrophage and astrocyte adhesion in an in vitro model of central nervous system catheter obstruction. J Biomed Mater Res 97A: 433-440. PubMed

Harris CA, Resau JH, Hudson EA, West RA, Moon C, Black AD, McAllister JP. 2011. Reduction of protein adsorption and macrophage and astrocyte adhesion on ventricular catheters by polyethylene glycol and N-aceytl-L-cysteine. J Biomed Mater Res 98A(4):425-433. PubMed

He Y, Xu Y, Zhang C, Gao X, Dykema KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, Xu HE. 2011. Identification of a lysosomal pathway that modulates glucocorticoid signaling and inflammation response. Sci Signal 4(180):ra44. PubMed

Hostetter G, Kim S, Savage S, Gooden G, Alla L, Barrett M, Zhang J, Watanabe A, Einspahr J, Alberts D, Prasad A, Nickoloff B, Carpten J, Trent J, Bittner M. 2010. Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples. Nucleic Acids Res 38(2):e9. PubMed

Demeure MJ, Sielaff T, Koep L, Prinz R, Moser AJ, Zeh H, Hostetter G, Black J, Decker A, Rosewell R, Bussey K, Von Hoff, DD. 2010. Multi-institutional tumor banking: lessons learned from a pancreatic cancer biospecimens repository. Pancreas 39(7): 949-954. PubMed

Wen F, Shen A, Shanas R, Bhattacharyya A, Lian F, Hostetter G, Shi J.  2010. Higher expression of the heterogeneous nuclear ribonucleoprotein K in melanoma. Ann Surg Oncol 17(10):2619- 27. PubMed

Hostetter G, Kim S, Savage S, Gooden G, Alla L, Barrett M, Zhang J, Watanabe A, Einspahr J, Alberts D, Prasad A, Nickoloff B, Carpten J, Trent J, Bittner M. 2010. Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples. Nucleic Acids Res 38(2):e9. PubMed

Harris CA, Resau JH, Hudson EA, West RA, Moon C, McAllister JP. 2010. Mechanical contributions to astrocyte adhesion using a novel in vitro model of catheter obstruction. Exp Neurol 222(2): 204-210. PubMed

Wang X, Wang S, Tang X, Zhang A, Grabinski T, Guo Z, Hudson EA, Berghuis B, Webb CP, Zhao P, Cao B. 2010. Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients. J Immunol Methods 362(1-2):151-160. PubMed

Knudsen BS, Zhao P, Resau J, Cottingham S, Gherardi E, Xu E, Berguis B, Daugherty J, Grabinski T, Toro J, Giambernardi T, Skinner RS, Gross M, Hudson EA, Kort E, Lengyel E, Ventura A, West RA, Xie Q, Hay R, Vande Woude GF, Cao B. 2009. A novel multipurpose monoclonal antibody for evaluating human c-MET expression in preclinical and clinical settings. Appl Immunohistochem Mol Morph 17(1): 57-67. PubMed

Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE. 2007. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448(7152):439-444. PubMed

Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, Hostetter G, Harvey J, Taubman MB. 2007. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res 13(10):2870-2875. PubMed

Tran NL, McDonough WS, Savitch BA, Fortin SP, Winkles JA, Symons M, Nakada M, Cunliffe HE, Hostetter G, Hoelzinger DB, Rennert JL, Michaelson JS, Burkly LC, Lipinski CA, Loftus JC, Mariani L, Berens ME. 2006. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and Nuclear Factor-{kappa}B and correlate with poor patient outcome. Cancer Res 66(19):9535-9542. PubMed

Watanabe A, Cornelison R, Hostetter G. 2005. Tissue microarrays: applications in genomic research. Expert Rev Mol Diagn 5(2):171-81. PubMed

Hu YC, Komorowski RA, Graewin S, Hostetter G, Kallioniemi OP, Pitt HA, Ahrendt SA. 2003. Thymidylatesynthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer.  Clin Cancer Res 9(11):4165-4171. PubMed

Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, Moses TY, Hostetter G, Wagner U, Kakareka J, Salem G, Pohida T, Heenan P, Duray P, Kallioniemi O-P, Hayward NK, Trent JM, Meltzer PS. 2003. High frequency of BRAF mutations in nevi.  Nat Genet 33:19-3320. PubMed

Weeraratna A, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM. 2002. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Can Cell 1(3):279-288. PubMed

Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephen D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, DeMarzo A, Papadopoulous N, Kallioniemi O-P, Burk R, Meyers D, Gronberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J. 2002. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet 30:181-184. PubMed

Andersen CL, Hostetter G, Grigoryan A, Sauter G, Kallioniemi A. 2001. Improved protocol for fluorescence in situ hybridization on tissue microarrays. Cytometry 45:83-86. PubMed